He served as District Nazim of Taunsa Sharif from 2001 to 2008. Mr. Usman Buzdar belongs to the Buzdar clan, which is a Baloch tribe.
Received his early education from Government Boys Primary School in Barthi, Punjab. He completed his Intermediate-level education from a Government College in Multan.
He received a master's degree in political science from Bahauddin Zakariya University and received a degree of bachelor of laws from the Law College, Multan.
Journey with PTI:
He joined Janoobi Punjab Suba Mahaz prior to the 2018 general election. Janoobi Punjab Suba Mahaz merged with Pakistan Tehreek-e-Insaf in May 2018. Buzdar joined PTI and was allocated PTI ticket to contest the 2018 general election from Constituency PP-286 Dera Ghazi Khan-II
He was elected to the Provincial Assembly of Punjab as a candidate of PTI from Constituency PP-286. He received 26,897 votes
On 17 August 2018, Imran Khan nominated him as PTI's candidate for the office of Chief Minister of Punjab.
He was elected as the Chief Minister of Punjab. He received 186 votes against his opponent Hamza Shahbaz Sharif who secured 159 votes. He was sworn in as Chief Minister of Punjab on 20 August 2018.